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Examples of oligomers with mismatched bases are provided in FIG. 7 as "mm." The specific mismatched base-pairs are bolded, underlined, italicized, and highlighted. Examples of oligomers with mismatched bases are provided in FIG. 4 as "mm." The specific mismatched base-pairs are bolded, underlined, italicized, and highlighted. FIG. 4: shows the impact of Tau antisense oligonucleotide on spontaneous calcium oscillations in primary neurons. The term "oligomer" in the context of the present invention, refers to a molecule formed by covalent linkage of two or more nucleotides (i.e., an oligonucleotide). The term "polynucleotide" as used herein refers to two or more nucleotides linked in sequence. Furthermore, "and/or" where used herein is to be taken as specific disclosure of each of the two specified features or components with or without the other. For example, the Concise Dictionary of Biomedicine and Molecular Biology, girl web cams Juo, Pei-Show, 2nd ed., 2002, CRC Press; The Dictionary of Cell and Molecular Biology, 3rd ed., 1999, Academic Press; and the Oxford Dictionary Of Biochemistry And Molecular Biology, Revised, 2000, Oxford University Press, provide one of skill with a general dictionary of many of the terms used in this disclosure.  
  
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure is related. Check out our video where we guess the meaning of different sex toys. Enjoy the widest selection of Webcam Sex Models available for Adult Chat - teens, naked girl ass matures, MILFS, ebony girls, real amateurs, babes and many others - all these gorgeous Cam Girls are ready to Live Porn Chat with you! SoP has dirty talk, audio from people having sex with themselves or others, and JOI (jerk-off instructions). In certain embodiments, the term "nucleotide analogs" refers to nucleotides having modified sugar moieties. In other embodiments, the term "nucleotide analogs" refers to nucleotides having modified base moieties. Exemplary polynucleotides can comprise a nucleotide sequence having two nucleotides, three nucleotides, four nucleotides, five nucleotides, six nucleotides, seven nucleotides, eight nucleotides, nine nucleotides, ten nucleotides, oligonucleotides, 50 nucleotides, 51 nucleotides, or more.  
  
The term "nucleic acids," "nucleotides," "nucleotide sequence," or "nucleic acid sequence" is intended to encompass plural nucleic acids (e.g., two or more, three or more, etc.). Over the past year or so, Mark has had just three dates, including (he thinks) one kiss, but it was so long ago he can barely remember. Cams - Cams have been an amazing money maker through the years improving year over year for all involved. The late Whitney Houston may have gone on tour this week in the form of a hologram, but classical star Carly Paoli is going one better by performing a duet with a singer who died more than 60 year ago. Units, prefixes, and symbols are denoted in their Systeme International de Unites (SI) accepted form. The headings provided herein are not limitations of the various aspects of the disclosure, which can be had by reference to the specification as a whole.  
  
Generally the age line divided as 18-25, 25-35, 35-45 and 45-50. Other ease of searching is provided by the category wise division of the places, caste and even suitable keywords describing the body features so that the users can find their choices more quickly. In fact, you can remain completely anonymous until you find an individual that you truly desire to meet in real life and you wish to take the relationship to a new level. In case you follow these suggestions, you may find some excellent individuals and have a lot of fun! Want some sorority fun? Again you may want to put it in the fridge for a while to cool. FIG. 4 lists the oligomer name, ASO identification number, ASO sequence, SEQ ID Number, target start and end positions on the MAPT pre-mRNA sequence, and calcium oscillation data as a percent of control (as discussed in Example 2 below).